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Insulin is a protein secreted by the pancreas which acts on the liver to stimulate the formation of glycogen from glucose and to inhibit the conversion of non-carbohydrates into glucose. Insulin also promotes facilitated diffusion of glucose through cells with insulin receptors, and of course this means muscle tissue. As you may expect, very high concentrations of insulin have been soundly result in markedly stimulated muscle protein synthesis. It does this mainly at the translational level by enhancing peptide chain initiation. This property and its consequent results are probably the things which makes it most interesting to bodybuilders and athletes. This is because those factors combine to make ingested protein more efficient by promoting the transport of amino acids into muscle cells. Ergo, we can clearly say that insulin is undoubtedly anabolic in muscle tissue. It also has an anabolic effect in bone, and thereby increases bone density as well. Another mechanism by which insulin is anabolic is via increasing your bodys IGF (Insulin-like Growth Factor) levels (6. IGF is an extremely anabolic hormone
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Another unexpected aspect of insulin use is its ability to increase both LH (Leutenizing Hormone) and FSH (Follicle Stimulating Hormone), both of which in turn stimulate testosterone production. What Im getting at here is that insulin stimulates gonadotropin secretion, meaning that its use may actually provide an anabolic effect through increasing your HPTAs ability to stimulate the production of testosterone (Hypothalamic-Pituitary-Testicular-Axis) This effect is often manifested as virilization (development of male sexual characteristics) in women. Insulin also increases the binding ability of anabolic steroids to the androgen receptors ,which would clearly suggest strongly the possibility of a synergistic effect of insulin when combined with steroids. Most people also think that insulin has some anabolic synergy when combined with growth hormone, and certainly there is a lot of anecdotal evidence for this as well. In addition to anecdotal research, its important to note that Insulin is actually so anabolic that some researchers have speculated that Growth Hormones (GH) ability to stimulate Protein Synthesis may actually be,in part, due to GHs ability to increase insulin sensitivity (12). Certainly the complex relationship between insulin, IGF, and GH is very synergistic and all interrelated to each others actions (13) (15) (16) (17). Using all three of them plus anabolic steroids and a fat-burner is the most potent muscle-building & fat -burning cycle possible.
Of course, when something seems too good to be true, it usually is. Unfortunately, the bad news is that insulin can easily stimulate adipose (fat) storage. Generally, though, most bodybuilders take insulin with a fat burner or 2 (Thyroid meds are the most popular choice), as well as anabolic steroids and sometimes even GH and IGF, for reasons previously explained. All of this adds up to decreasing the chance that fat is stored, and greatly increases the amount of muscle that will be gained.
Anyway, as you probably guessed, endogenous insulin (the stuff naturally found in your body) operates on feedback from within your body.
When your glucose levels get high, which is what happens when you eat a sugary snack, insulin is then released from your beta cells. When glucose is low, insulin is, of course, low.
In fact, simply adding liquid glucose to a liquid amino-acid meal (thereby raising insulin levels) will increase the absorption of the ingested amino acids by roughly 50% Now, think about this: If a natural insulin response to ingested glucose can give you 50% better absorption of protein, think about how much protein absorption injecting it will give you..
So, now that we have some kind of understanding as to what endogenous insulin does, lets try to figure out exactly what exogenous insulin can do (thats the kind you get from a bottle..). Medically, of course, insulin is used to treat diabetes...thus becoming diabetic is a real risk with improper insulin usage.
First, Im going to give you some clinical examples of how insulin has been used as an anti-catabolic agent. In the first study I read, insulin levels were increased 15-fold in infants suffering extreme catabolism. This level of insulin administration produced a 32% reduction in protein breakdown. In the second study I read exogenous insulin impeded muscle protein loss in burn victims (5). Its important to note that you MUST have enough amino acids (protein) in your body for insulin to exert an anabolic effect. If there are not enough amino acids floating around in your body from your last few meals, insulin will not be anabolic at all. On the other hand, If amino acid concentrations are maintained at normal or high levels as they would be in a typical athlete or bodybuilders diet, a net protein deposition in muscle will occur (more protein deposited in your muscle = more muscle gained). This effect of insulin depositing protein in your muscles is primarily because of an actual stimulation of protein synthesis and also owing to an inhibition of protein breakdown . The lesson here is that even with insulin, diet is the key to it all. You need to have enough protein in order to build muscle, regardless of how much insulin you take.
